Until today, MRI in epilepsy has focused on neurostructural pathologies causing seizures, whereas the epileptic seizures as such, albeit being the pathognomonic symptoms of epilepsy, have not received any attention. Here, we want to establish functional MR imaging of epileptic seizures by sensitizing our MRI signal and data postprocessing for what is commonly known as transient peri-ictal MRI changes. As epileptic seizures of patients may not directly be observed in the scanner for pragmatic reasons, the idea is to post-hoc visualize microstructural processes anatomically and temporally related to individual seizures, such as peri-ictal blood-brain barrier dysfunction (Rüber, David et al., 2018a) or postictal hypoperfusion (Gaxiola-Valdez et al., 2017). First studies in our group have confirmed that peri-ictal blood-brain barrier dysfunction may be measured by means of post-ictal quantitative MRI after ictal injection of Gadolinium and could be visualized peri-focally after elaborate postprocessing on a single-subject level (see figure). The ictal injection of Gadolinum, however, is time-consuming and the medical harmlessness of Gadolinium itself is in the focus of a controversial scientific debate. In collaboration with Professor Tony Stöcker from the DZNE, an Arterial Spin Labeling MR sequence is being developed which may measure both at the same time: blood-brain barrier permeability and perfusion by means of an endogenous tracer, i.e. without exogenous contrast agent application (and, thus, without the need for a technical-assistant observing the patient to ensure strictly ictal injection of contrast agent).